• The focus of this review is on the diacylglycerol

  2020-03-16

  

  The focus of this review is on the diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) enzymes, DGAT1 and DGAT2, that catalyze the esterification of a fatty acyl moiety to a DAG molecule to produce TAG. These enzymes commit DAG to being stored as TAG rather than being diverted for the synthesis of ph

• Introduction Cytochrome P CYP A is the most important

  2020-03-16

  

  Introduction Cytochrome P450 (CYP)3A is the most important enzyme involved in the metabolism of 30–40% of currently prescribed drugs [1]. The trpv1 level and activity of CYP3A show large intra- and inter-individual variability, which contributes to unpredictable drug response and toxicity. A multi

• Unlike the CRF receptor the CRF a receptor

  2020-03-16

  

  Unlike the CRF1 receptor, the CRF2(a) receptor binds and is activated by agonists with a broad range of potencies. Therefore, we assessed the ability of strong and weak ligands to desensitize retinoblastoma CRF2(a) receptors. Although stresscopin\'s N-terminus is two Octyl-α-ketoglutarate longer tha

• Regarding the mechanism of action of

  2020-03-16

  

  Regarding the mechanism of action of CRF, several studies have shown that low doses of CRF may preferentially activate CRF1 receptors in glutamatergic projection neurons, serotoninergic neurons or glutamatergic collaterals in the medial prefrontal cortex (Vertes, 2004). Indeed, prosencephalic inacti

• Acknowledgments The authors thank Dr Vladimir Poltoratsky an

  2020-03-16

  

  Acknowledgments The authors thank Dr. Vladimir Poltoratsky and Zhihui Xiao for their help with the in vitro FRET assay. Support for this research was provided by Saint John’s University. Introduction We predicted the existence of endothelium-derived contractile factors (EDCFs) in 1982 [1]. In 1

• The upregulation of PTGS and PTGS

  2020-03-16

  

  The upregulation of PTGS1 and PTGS2 in late gestation in mares could be linked to the high levels of estrogens produced by the fetoplacental unit. Estrogens are thought to be effective stimulators of prostaglandin production by potentially up regulating PTGS2 expression. Although a recent publicatio

• Acknowledgments br Introduction Steroidogenesis the process

  2020-03-16

  

  Acknowledgments Introduction Steroidogenesis, the process of testosterone synthesis, occurs in the adrenal cortex, testis and ovary, and it is controlled by luteinizing hormone (LH), which is synthesized and secreted from the pituitary (Hanukoglu, 1992, Payne and Youngblood, 1995). In the testis

• In different body organs a number of biological functions ar

  2020-03-16

  

  In different body organs, a number of biological functions are generally mediated by binding of the extracellular substances to the particular transmembrane receptors, which results in subsequent signal stimulation by intracellular signaling cascades. These cascades function over the complex network

• On the other hand although the cardiovascular effects of

  2020-03-16

  

  On the other hand, although the cardiovascular effects of Epac have been investigated more intensely in recent years [31], there are hardly any studies that suggest or discard a participation of Epac in endothelium-dependent cAMP-induced relaxation. Only our previous results in rat Annexin V-Cy3 Apo

• EP receptor is known to mediate the protective

  2020-03-16

  

  EP4 receptor is known to mediate the protective effect of PGE2 on the respiratory, gastrointestinal and glomerular epithelial lining (Aoudjit et al, 2006, Kabashima et al, 2002, Schmidt et al, 2011). In this study, the expression of asEP4 in the gills was limited to the epithelial lining suggesting

• br Summary and perspectives In recent decades enormous advan

  2020-03-16

  

  Summary and perspectives In recent decades, enormous advances have been achieved in the development of enzyme-activatable imaging probes, enabling the accurate detection of enzyme activity in vivo to better understand the biological function of enzymes in disease processes. Activatable probes are

• br A brief introduction to DUBs The

  2020-03-13

  

  A brief introduction to DUBs The reversal of ubiquitin conjugation of targeted proteins relies on deubiquitinating Tideglusib (DUBs), which catalytically cleave single Ub or poly-ubiquitin chains from proteins. The human genome encodes approximately 100 potential DUBs which can be classified int

• In Arabidopsis the quartet qrt mutant enables the same

  2020-03-13

  

  In Arabidopsis the quartet1 (qrt1) mutant enables the same type of analysis of gametophytes (pollen) in sets of four (tetrads) derived from individual meioses 61., 62.. Pollen tetrads from one accession (Columbia-0) are used to pollinate a second polymorphic accessions (Landsberg erecta) resulting i

• We used two different VSMCs

  2020-03-13

  

  We used two different VSMCs cell lines, KSB and CSD (isolated from two different thoracic aortas). Rat aortic VSMCs were isolated from medial segments from thoracic rate leukotriene synthesis from Wistar-Kyoto rats (six to eight weeks old, Charles River Wiga GmbH) and cultured over several passages

• br The role of chemokine and AD Chemokines are small

  2020-03-13

  

  The role of chemokine and AD Chemokines are small cytokine proteins that are involved in various immunological and physiological functions. These proteins can be involved in cell migration and localization during homeostasis and inflammation, and as such, they were named chemokines [80]. Chemokin

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