• br The need for modified therapeutic proteins and why

  2020-08-05

  

  The need for modified therapeutic proteins and why they need to last longer in the body Chemical and structural changes in therapeutic proteins are possible and are carried out frequently to accomplish pharmacological or clinical benefit. Such modifications are essential as the drug needs to pass

• br Materials and methods br Results and discussion br

  2020-08-05

  

  Materials and methods Results and discussion Concluding remarks The successful knockout of the tpi1 gene in K. pneumoniae DSM2026 and the physiological study of mutants grown on different carbon sources led to the discovery of a novel tpi2 gene in this bacterium. The direct enzyme assay and

• COMT protein expression was investigated as a potential

  2020-08-05

  

  COMT protein NP118809 was investigated as a potential mechanism by which tolcapone may differentially affect male and female P and Wistar rats. COMT protein levels in the PFC were lower in P rats compared to Wistars but female P rats expressed greater levels of COMT in the PFC relative to males. En

• To check the reusability of the catalyst

  2020-08-05

  

  To check the reusability of the catalyst, the reaction of 4-chlorobenzyl alcohol and acetic anhydride under the optimized reaction conditions was studied. When the reaction was completed, dichloromethane was added and the catalyst was separated by filtration. The recovered catalyst was washed with d

• 4-ethylphenyl sulfate A structural model for the unprecedent

  2020-08-05

  

  A structural model for the unprecedented interactions between UBE2S, its target (i.e., a Ub that has been linked already to an APC/C substrate), and APC/C was generated by hybrid structural studies merging information from NMR, crosslinking, and mutational data with a low-resolution cryo-EM map of A

• br Introduction Arsenic compounds or arsenicals are well kno

  2020-08-04

  

  Introduction Arsenic compounds or arsenicals are well-known toxic and carcinogenic agents (IARC, 1980, Wang et al., 2002). The genotoxic and co-genotoxic effects of inorganic arsenicals are well documented in mammalian systems, both in vitro (Jha et al., 1992) and in vivo (Tice et al., 1997). A n

• Accumulating data show that NPC L exerts a proatherogenic ef

  2020-08-04

  

  Accumulating data show that NPC1L1 exerts a proatherogenic effect. For example, in low-density lipoprotein (LDL) receptor (Ldlr) mice with gastrointestinal tract-specific overexpression of NPC1L1, cholesterol feeding markedly promotes intestinal cholesterol Cathepsin Inhibitor 1 and causes hypercho

• Recent studies show that the expression and function

  2020-08-04

  

  Recent studies show that the expression and function of some ion channels such as voltage-gated potassium channels, sodium channels and calcium channels are closely related to the proliferation, migration, and invasion of tumor cells [40], [41], [42]. Firstly, the expression of ion channels is chang

• br Introduction Endothelins ETs are a

  2020-08-04

  

  Introduction Endothelins (ETs) are a family of multifunctional, naturally occurring peptides with long-lasting vasoconstrictor and pressor effects (Zhou et al., 2004). They are synthesized as a large protein, the pre-proET-1 or Big ET-1, which is subsequently cleaved to pro-ET-1 and then ET-1 by

• The Penicillium strain used in this work was isolated from

  2020-08-04

  

  The Penicillium strain used in this work was isolated from Atlantic forest soil and previously screened as lipase producer (Tauk-Tornisielo et al., 2005). The immobilization was previously evaluated using hydrophobic supports, i.e. agarose based butyl-(But), phenyl-(Phe) and octyl-Sepharose (Oct), a

• TgTCEA from petals TgTCEA and

  2020-08-04

  

  TgTCEA from petals (TgTCEA1) and TgTCEB from pollen grains (TgTCEB1) were used throughout the study. The recombinant CW069 australia were expressed in , and purified as the His-tag-free forms as described previously., Enzyme reactions were performed at 4 mM substrates under the same conditions as

• Here we have used transcriptome analysis of primary neonatal

  2020-08-04

  

  Here, we have used transcriptome analysis of primary neonatal rat cardiomyocytes treated with either the ETR agonist endothelin-1 or the α1-AR agonist phenylephrine to assess differences in their respective signalling networks, and further probed these differences using a panel of fluorescent resona

• br Results and discussion br Conclusion We have constructed

  2020-08-04

  

  Results and discussion Conclusion We have constructed a series of potent and greatly selective DPP-4 inhibitors with pyrazolo[1,5-a]pyrimidin-7(4H)-one core surrogates. The modification of the core led us to b2 which has IC50 of 80 nM and > 1000 fold selectivity over DPP-8 and DPP-9. We utiliz

• DGK metabolizes DG which enhances PKC activity DGK

  2020-08-04

  

  DGK metabolizes DG, which enhances PKC activity [10,11]. DGKδ regulates the EGFR pathway for the epithelial cell differentiation of lungs and skin [27] and controls insulin receptor signaling for glucose uptake in skeletal muscle [20] by attenuating cnPKC activities. In this study, we found that the

• Morimoto et al established a novel process

  2020-08-04

  

  Morimoto et al. established a novel process for mass production of d-gulose from an inexpensive lactose derivative. The highest keto-sugar conversion reported was 83%, while the maximum productivity was 0.0537 g/OD/L/h [30]. Adopting their method with a few modifications, recombinant E. coli Thymidi

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