• Currently phosphodiesterase type PDE inhibitors are used wid

  2020-09-07

  

  Currently, phosphodiesterase type 5 (PDE-5) inhibitors are used widely as the first- line oral treatment for erectile dysfunction of varying causes. Radical prostatectomy for the treatment of prostate cancer is frequently associated with erectile dysfunction, and this type of erectile dysfunction is

• Introduction Human cytomegalovirus CMV is

  2020-09-07

  

  Introduction Human cytomegalovirus (CMV) is a herpesvirus which has a ubiquitous and worldwide distribution, and is the most frequent cause of congenital infection (Kenneson and Cannon, 2007). The prevalence is around 0.5–1% of all live births and is the leading cause of sensorineural hearing loss

• Our results for imidacloprid were unexpected considering tha

  2020-09-07

  

  Our results for imidacloprid were unexpected: considering that imidacloprid (Im) is a neonicotinoid insecticide with a different mode of action (agonist of the nicotinic Gap19 receptor) than OPs, we expected Es-ChE and T-ChE activity to be largely insensitive to changes in Im concentrations. Howeve

• Theoretically the expression profile of GluCl

  2020-09-07

  

  Theoretically, the expression profile of GluCl variants was related to their physiological roles. It was reported that all the three variants (GluCl A, GluCl B, GluCl C) were highly expressed in head tissue of L. striatellus and M. domestica, and the expression level of GluCl A was significantly hig

• Replacement of the saturated propoxy group in compound with

  2020-09-07

  

  Replacement of the saturated -propoxy group in compound with the unsaturated allyloxy group to obtain compound resulted in 10-fold decrease in ET receptor antagonism and more than 20-fold decrease in ET-selectivity. Analogous unsaturated allyloxy compound in the tetrazole series was found to have

• br Chemistry The test compounds listed

  2020-09-07

  

  Chemistry The test compounds listed in Table 1, Table 2, Table 3, Table 4, Table 5, were synthesized as outlined in Scheme 1, Scheme 2, Scheme 3, Scheme 4, Scheme 5. Synthesis of 2–5 is described in Scheme 1. N-Sulfonylation of the aniline 26 with benzenesulfonyl chloride afforded the sulfonamide

• Artificial permutations have also been exploited by

  2020-09-07

  

  Artificial permutations have also been exploited by protein engineering to manipulate protein scaffolds, in order to improve catalytic activity, alter substrate or ligand binding affinity, reduce proteolytic susceptibility, increase stability, generate different aggregation states and improve fluore

• Hyaluronic acid HA also called hyaluronan

  2020-09-07

  

  Hyaluronic BLU 9931 synthesis (HA), also called hyaluronan is widely distributed in Extra Cellular Matrix of soft connective tissues including skin, umbilical cord and synofial fluid (Hanamura et al., 2008). Hyaluronic acid has a unique ability to hold 6000mL of water in 1mg of HA and plays an impo

• Developmental relationships between CD bright and CD

  2020-09-07

  

  Developmental relationships between CD56bright and CD56dim NK Bleomycin Sulfate remain unresolved; however, several studies indicate that the former is a precursor of the latter. An NK subset with intermediate features between CD56bright and CD56dim has been identified, corroborating this developme

• br Diverse functions of ERK pathway Same as

  2020-09-05

  

  Diverse functions of ERK pathway Same as the other MAPK cascades, the ERK pathway is activated by several extracellular stimuli and different internal routes. ERK vitally tunes the function of various substrates in all cellular components; the nucleus, cytoplasm, membranes and the cytoskeleton. E

• Cinobufagin receptor DAPK is a kD Ca calmodulin CaM regulate

  2020-09-05

  

  DAPK is a 160-kD Ca2+/calmodulin (CaM)-regulated Ser/Thr kinase that mediates cell death. The activated forms of DAPK and DRP-1 are capable of inducing two distinct cytoplasmic events characteristic of programmed cell death, including membrane blebbing and the formation of autophagic vesicles (Inbal

• br Diseases which have been treated with proteins linked

  2020-09-05

  

  Diseases which have been treated with proteins linked to HSA A number of therapeutic products conjugated to HSA have now been approved for clinical use (Table 2). For example, fatty Nilotinib derivatives of human insulin bound to HSA have applications in the treatment of diabetes while paclitaxe

• br Materials and methods br Results br Discussion

  2020-09-04

  

  Materials and methods Results Discussion Persimmon tannin has been reported to have the bile acid binding ability in vitro (Matsumoto et al., 2011) and hypolipidaemic effects in animals (Matsumoto et al, 2008, Zou et al, 2012). Our previous study also proved that persimmon tannin promoted t

• The contribution of local ETA

  2020-09-04

  

  The contribution of local ETA and ETB receptors towards heat hyperalgesia induced by inoculation of XC tumor Etoposide in the paw of mice has been demonstrated by Baamonde and colleagues (Baamonde et al., 2004). Furthermore, using neuropathic and inflammatory nociception models, several studies hav

• Methods br Results br Discussion It is well established that

  2020-09-04

  

  Methods Results Discussion It is well established that CRSwNP is characterized by TH2 inflammation and eosinophilia.22, 27 Yet it is becoming increasingly apparent that B cells might play an important role in the inflammatory response within the sinus tissue of patients with CRSwNP.8, 9 The l

16043 records 808/1070 page Previous Next First page 上5页 806807808809810 下5页 Last page