• br Acknowledgment We thank Professor Yuh Chang Sun

  2020-09-19

  

  Acknowledgment We thank Professor Yuh-Chang Sun for providing helpful advice and the Ministry of Science and Technology of the Republic of China for financial support (grants MOST ). Introduction Past century has witnessed a tremendous increase in life expectancy of the human population, achi

• PKA signalling in the nucleus was

  2020-09-19

  

  PKA signalling in the nucleus was thought to be due to the translocation of the catalytic subunit upon activation from the cantharidin to the nucleus via diffusion [72]. However, a new understanding has emerged, as both the regulatory and catalytic subunits have been identified in the nucleus and f

• br Introduction Abdominal aortic aneurysm

  2020-09-19

  

  Introduction Abdominal aortic aneurysm (AAA) is a daily concern in vascular surgery, as successful treatment is exclusively achieved by open or endovascular repair. Its prevalence is 2–11% among male smokers, and rupture the major complication, is associated with unacceptably high morbidity and m

• Next we compared the protease specificity of viruses NS GFP

  2020-09-19

  

  Next, we compared the protease-specificity of viruses NS116-GFP/AE and NS116-GFP/AT for trypsin, neutrophilic elastase or supernatant of human neutrophils. For later purposes, we determined the viral yield in a co-cultivation system of infected Vero PD173955 with human neutrophils. The NS116-GFP/el

• br Introduction Epidermal growth factor

  2020-09-18

  

  Introduction Epidermal growth factor receptor (EGFR)-activating-mutant non-small cell lung cancer (NSCLC) often initially responds well to EGFR tyrosine kinase inhibitors (TKIs) (Haber et al., 2011); however, the disease almost always recurs about 10–13 months of therapy. Analysis of clinical spe

• At present there have been relatively few studies that

  2020-09-18

  

  At present, there have been relatively few studies that evaluated potential correlations between pulmonary and pleura metastases, hilar and mediastinal 12-O-tetradecanoyl phorbol-13-acetate nodes, and organs associated with distant metastasis and EGFR mutations [33,34,37]. Further research on these

• Although the amino acid sequences of CUL A and CUL

  2020-09-18

  

  Although the amino dna topoisomerase sequences of CUL4A and CUL4B share 82% identity, the existing studies have shown that these two proteins do not have significant functional redundancy. Elevated expression of CUL4A has been observed in a variety of cancer cells, such as breast cancer, ovarian can

• Here we discuss implications of several major families of

  2020-09-18

  

  Here, we discuss implications of several major families of RING-type E3 ubiquitin ligases (MDM, Cullin, GRAIL, TRAF, TRIM) as targets in inflammation and immunity, and provide insights into potential small molecule interventions to mediate the cellular responses (summarized in Table 1). We briefly

• A role for the E

  2020-09-18

  

  A role for the E2–E3 interface in governing mono- versus polyubiquitination is not mutually exclusive with that of the E2 backside, which has previously been shown to mediate polyubiquitination through its ability to bind to Ub [21], [25], [33]. Brzovic and colleagues first demonstrated the importan

• In the SUMOylation pathway SCE as

  2020-09-18

  

  In the SUMOylation pathway, SCE1 as an E2 enzyme has an important role in mediating the conjugation of SUMO to target proteins. The accumulated SUMO conjugates in plants are associated with abiotic stress responses (Castro et al, 2012). We performed a drought stress analysis on WT plants, induced by

• br Introduction Type Diabetes mellitus T

  2020-09-18

  

  Introduction Type 2 Diabetes mellitus (T2DM) is a metabolic disorder that raises blood glucose level for a prolonged time. T2DM is associated with acute complications like ketoacidosis, hyposmolar coma, chronic complications include heart disease, stroke, kidney failure, foot ulcers and damage to

• In conclusion we have found that Egr can play an

  2020-09-18

  

  In conclusion, we have found that Egr1 can play an inhibitory role on DBH promoter-driven transcription. This inhibition requires a newly identified Egr1 response HC-030031 mg at the −227/−224 region of DBH promoter. This inhibition appears to result from Egr1 directly bound to the DBH promoter. We

• Several DA receptors heteromers with a therapeutic

  2020-09-18

  

  Several DA receptors heteromers with a therapeutic potential have been described, including D1R/D3R (Fiorentini et al., 2010), but their roles remain to be established. Moreover, most studies on receptor heteromers in addiction focused on the striatum because of its key role in the pathology and its

• In the case of high fidelity polymerases we

  2020-09-18

  

  In the case of high-fidelity polymerases, we propose that water is used to achieve negative selection against nucleotide binding. With specialized DNA polymerases, we propose that nucleobase desolvation plays a different yet important role in allowing these enzymes to replicate damaged DNA. In this

• Recently naphthoquinone derivatives have shown promising res

  2020-09-18

  

  Recently, naphthoquinone derivatives have shown promising results as antiparasitic lead compounds [28]. Conjugated hybrid compounds could be an effective path to discovery of new drugs by associating two different pharmacophore groups with different mechanisms of action in a single molecule [29,30],

16096 records 806/1074 page Previous Next First page 上5页 806807808809810 下5页 Last page