• Growing evidence suggests that the glycine site seems to pla

  2022-02-12

  

  Growing evidence suggests that the glycine site seems to play a pivotal role in NMDAR-related function. For example, it Boc-D-FMK has been demonstrated in a hippocampal slice study that the glycine site sub-serves the spatiotemporal detection of synaptic activity (Li et al., 2009). Moreover, mice w

• Glial cells have emerged as important protagonists of the ce

  2022-02-12

  

  Glial cells have emerged as important protagonists of the central nervous system (CNS) physiology (Chen and Swanson, 2003; Kettenmann and Verkhratsky, 2008; Parpura and Verkhratsky, 2012). As widely described in the literature, astrocytes regulate glutamatergic synapses by clearance of glutamate in

• Na K ATPase adenosine triphosphate ATP and astrocytic glutam

  2022-02-12

  

  Na+/K+-ATPase, dihydrofolate reductase inhibitor antibacterial and astrocytic glutamate transporters act together to maintain sodium and potassium gradients and the proper activities of EAAT1 and EAAT2 (Rose et al., 2009; Sheean et al., 2013); nevertheless, in present study, Na+/K+-ATPase activity w

• Immunohistochemistry analysis shown ghrelin and GHSR a

  2022-02-12

  

  Immunohistochemistry analysis shown ghrelin and GHSR-1a immunostaining was located in the epithelial cells of 5-lipoxygenase and ducts throughout the lactation, strong immunoreactive cells were detected in L30, L60 and L120 stage. The distribution of ghrelin has been shown in many tissues, includin

• Caspase-3, human recombinant proteinase receptor A model sub

  2022-02-12

  

  A model substance often used in the studies of oxidative processes in erythrocytes is tert-butyl hydroperoxide (t-BHP), which, being lipophilic, passes easily across the erythrocyte membrane [9]. In erythrocytes treated with t-BHP (0.1–3mM) for less than 1h, a dramatic decline in the reduced glutath

• A single ICV injection of GALP stimulated

  2022-02-12

  

  A single ICV injection of GALP stimulated food intake in goldfish at 1h post-administration. This result is similar to that observed in rats, where ICV injection of GALP exerted an acute orexigenic effect [14], [15], [16]. Simultaneously, our findings counter the results found in mice, where central

• br Introduction Excitatory pyramidal neurons are generated i

  2022-02-11

  

  Introduction Excitatory pyramidal neurons are generated in the cortical ventricular zone and migrate into the cortical plate alongside the radial glial processes (Chanas-Sacre et al., 2000, Hartfuss et al., 2001, Noctor et al., 2001, Rakic, 1972, Tan et al., 1998). Neuronal migration determines t

• In this study we describe the

  2022-02-11

  

  In this study, we describe the role of a specific species of LPI in the secretion of GLP-1 from enteroendocrine L-cells and primary cell preparations. We further demonstrate the specific role of GPR119 in LPI-dependent GLP-1 secretion. To achieve this, we downregulated GPR119 and GPR55 protein expr

• br TGR Agonists br FXR TGR

  2022-02-11

  

  TGR5 Agonists FXR/TGR5 Dual Agonists In 2010, a FXR/TGR5 dual agonist, 51 (INT-767), was reported [57]. Using an AlphaScreen coactivator recruitment assay, the potency of 51 at FXR was 30nM. In NCI-H716 cells, 51 stimulated intracellular cAMP secretion with an EC50 of 0.63μM. Its TGR5 potency

• CD binding to gp causes

  2022-02-11

  

  CD4 binding to gp120 causes a large scale conformational change of gp120 which involves the gp120 core structure and the transitions of inner-domain layers (layer 1, 2 and 3), but also involves the movement of the major loops (V1, V2 and V3) [16], [17], [18], [19]. For instance, the V2-loop joins th

• In spite of the impressive

  2022-02-11

  

  In spite of the impressive progress made in DNA glycosylase assays in recent years, few of them have clearly been viable candidates for further development and implementation in biomedical research and clinical practice. Future research efforts should be devoted to devising assays with improved perf

• By regulation of synaptic glutamate concentration glutamate

  2022-02-11

  

  By regulation of synaptic glutamate concentration, glutamate transporters play an important role in limiting glutamate signaling and controlling the activation of glutamate receptors (Rimmele and Rosenberg, 2016). Reduced glutamate transport is thought to underlie the pathogenesis of numerous neurol

• br Materials and methods br Results br Discussion Ghrelin is

  2022-02-11

  

  Materials and methods Results Discussion Ghrelin is reported to regulate a number of processes related to cancer progression including tumor cell proliferation, apoptosis and metastasis [3,7,[15], [16], [17], [18], [19], [20], [21], [22]]. In the present study, we examined the potential eff

• Mesoridazine Besylate Ghrelin is mostly known for its

  2022-02-11

  

  Ghrelin is mostly known for its orexigenic properties, whereas the role of DAG on feeding is controversial with studies claiming an orexigenic, anorexigenic or no effect (Inhoff et al, 2009, Toshinai et al, 2006). One of these studies was that of Toshinai and colleagues, who found a link between the

• The waiting time for first

  2022-02-11

  

  The waiting time for first arrival of Lovastatin receptor into the dense fraction of 3–4 min at the normal chloride conductance, and about 30 min with inhibition to about 10% of the normal value, signifies that the Gardos channels in the activated cells become maximally or near maximally activated,

16099 records 515/1074 page Previous Next First page 上5页 511512513514515 下5页 Last page