• PKC s effect on quantal size may involve regulation of

  2022-05-05

  

  PKC’s effect on quantal size may involve regulation of endocytotic protein components responsible for mediating kiss-and-run exocytosis. There is a growing body of evidence to suggest that canonical endocytotic proteins—dynamin, amphiphysin, syndapin, and others—may play a role in modulating fusion

• Methods br Results br Discussion SV exocytosis from excitato

  2022-05-05

  

  Methods Results Discussion SV exocytosis from excitatory boutons is more sensitive to inhibition by isoflurane than exocytosis from inhibitory boutons,4, 31 but the mechanism(s) of this synaptic selectivity is unknown. Although P/Q-type VGCCs contributed quantitatively more to SV exocytosis t

• Materials and methods br Results and discussions

  2022-05-05

  

  Materials and methods Results and discussions Conclusions In this study, we identified 7 histone acetyltransferases and 12 histone deacetylases in Marchantia polymorpha. The present phylogenetic analysis of MpHATs and MpHDACs provide the insight into the evolutionary relationships of these tw

• Based on the in vitro findings summarized

  2022-05-04

  

  Based on the in vitro findings summarized here, we posited that, in the intact brain, release of ROS from iron-laden astrocytes to the local neuropil elicits oxidative damage and degeneration of indigent dopaminergic projections and other vulnerable neuronal elements (Schipper, 2001). Of particular

• Different crystal structures of both HOs were reported and s

  2022-05-04

  

  Different crystal structures of both HOs were reported and showed that the three-dimensional structures of proteins (HO-1: PDB code 1N45, HO-2: PDB code 2QPP) are predominantly in an α-helical conformation, with the heme packed between two helices (distal and proximal), and present a remarkable stru

• Urinary As species monomethylated MMAV percentage might incr

  2022-05-04

  

  Urinary As species monomethylated (MMAV) percentage might increase and As species dimethylated (DMAV) percentage might decrease with increasing As exposure dosage (Lindberg et al., 2008). The limited methylation capacity associated with increased of As exposure dosage might probably explained throug

• Immunohistochemical analysis of sheep skin sections showed t

  2022-05-04

  

  Immunohistochemical analysis of sheep skin sections showed that sGC prtotein is expressed in the hair follicles with different location and abundance between white and black sheep skin (Fig. 6). In white sheep skin, Strong sGC positive signal was detected in the upper hair dermal papilla but no posi

• Recently an increasing number of studies have highlighted th

  2022-05-04

  

  Recently, an increasing number of studies have highlighted the crucial role of nociceptive factors produced by microglia under neuropathic pain conditions (Mika et al., 2013; Popiolek-Barczyk and Mika, 2016). iNOS is an important pronociceptive factor that is strictly expressed by microglia/macropha

• br Expression profile of GPR As noted

  2022-05-04

  

  Expression profile of GPR35 As noted above, initial studies indicated expression of GPR35 in rat intestine [1] and stomach [2]. Subsequent studies have confirmed significant expression levels in the small intestine, colon and stomach, and this might be relevant in the association between a GPR35

• br Materials and methods br

  2022-05-04

  

  Materials and methods Results Discussion DNA repair pathways have evolved for a long time to act independently of one another. However, over the past decade several overlaps and crosstalks between these pathways were identified, showing that the DNA repair system is more complex than previo

• br Conclusion In summary a

  2022-05-04

  

  Conclusion In summary, a series of novel GPR40 agonists bearing phenylpropiolic desogestrel australia motif with favorable metabolic stability were prepared and evaluated for their activities as GPR40 agonists. Among them, compound 9 was identified as a structurally distinct GPR40 agonist posses

• A high fat maternal diet during the pregestation period

  2022-05-04

  

  A high-fat maternal diet during the pregestation period and extending throughout gestation (including the period of conception) has the propensity of affecting early embryonic development and placentation. Previous investigations have revealed that the preimplantation embryos are generally exposed t

• Cortisol targets many organs and

  2022-05-04

  

  Cortisol targets many organs and tissues and has certain effects on metabolism, including promoting glycolysis. It can cross the blood LMK 235 barrier and act centrally to regulate HPA axis activity by activating negative feedback mechanisms effectively, cortisol inhibits its own production (Fairch

• Regulation of pancreatic and cell

  2022-05-04

  

  Regulation of pancreatic α and β cell mass has been extensively studied and hotly debated, due to potential therapeutic implications. Early claims of Angptl8 as “betatrophin” and Angptl4 as a regulator of glucagon secretion and α cell proliferation (Yi et al., 2013, Ben-Zvi et al., 2015) have not st

• br Role of ghrelin in reward and

  2022-05-04

  

  Role of ghrelin in reward and addiction In addition to its well-known effects on isoxazole synthesis homeostasis regulation at the hypothalamic level [reviews in (Al Massadi et al., 2017, Muller et al., 2015)], ghrelin also has the ability to increase food motivation acting on hypothalamic and e

16046 records 463/1070 page Previous Next First page 上5页 461462463464465 下5页 Last page