• Programmed death ligand PD L expression is a characteristic

  2019-05-16

  

  Programmed death ligand 1 (PD-L1) expression is a characteristic feature of EBV-associated malignancies. Research has shown that an increase of PD-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma. Preliminary data from a phase Ib study, KEYNOTE-028, showed

• Preamble The J wave syndromes

  2019-05-16

  

  Preamble The J-wave syndromes (JWSs), consisting of the Brugada syndrome (BrS) and early repolarization syndrome (ERS), have captured the interest of the cardiology LJI308 over the past 2 decades following the identification of BrS as a new clinical entity by Pedro and Josep Brugada in 1992 [1]. T

• As en una parodia llevada

  2019-05-16

  

  Así, en una parodia llevada al extremo del absurdo de esta escritura blanca o vacía, Amélie descubre finalmente que los tesoros vivientes no escriben, sus libros son “maquetas empastadas con las hojas en blanco” (55). Tekendogo es un país donde la dictadura se legitima INCB018424 manufacturer través

• l-name br A tactical change in research and

  2019-05-16

  

  A tactical change in research and advocacy is needed urgently before mental health services will be made a priority in low-income and middle-income countries. Mental disorders and substance misuse are the greatest contributors to the global burden of disability, with 175·3 million years lost to di

• Vistos por lo tanto desde la ideolog a revolucionaria ascend

  2019-05-15

  

  Vistos, por lo tanto, desde la ideología revolucionaria ascendente, los marginales/campesinos conformaron, más que una presencia ciudadana, en sentido moderno, una especie de sensibilidad motivadora en la que se autorrecreaba una ontología de lo nacional. Esta fuerza fue muy importante en la articul

• La propia Mirna Paiz rescata en sus memorias cu l

  2019-05-15

  

  La propia Mirna Paiz rescata en sus memorias cuál fue su papel en la guerrilla, dejando claro que si bien en algunas ocasiones tuvo apexbio dilution su cargo la administración y distribución de medicinas, su labor no era ser costurera. La decisión editorial de cubrir su rostro e incluso excluirla d

• En otra rbita George Y

  2019-05-15

  

  En otra órbita, George Yúdice establece una doble genealogía refiriéndose al testimonio que se realiza sodium butyrate partir de la información que proporciona un sujeto subalterno a un escritor o a un intelectual. Yúdice se refiere aquí a la pedagogía de los oprimidos de Paulo Freire y a la Teolog

• Di logo de amigos escritura y ficci n

  2019-05-15

  

  Diálogo de amigos, escritura y ficción se cruzan desde las primeras páginas: “Por dispares que fuéramos como escritores, la amistad cabía, porque sentíamos una compartida pasión por los libros. Tardes y noches conversamos de Johnson, de De Quincey, de Stevenson, de literatura fantástica, de argument

• Prednisone prephase was initiated and led to immediate

  2019-05-15

  

  Prednisone prephase was initiated and led to immediate improvement of clinical status. However, tumour size did not decrease within the prolonged prephase of 11 days (Fig. 1b). Despite additional cyclophosphamide (2×200mg/m2), the patient showed deteriorating clinical condition and fever reappeared

• Between February and November we conducted

  2019-05-15

  

  Between February and November, 2015, we conducted a priority-setting exercise to set research priorities for ECD to 2025. This is part of WHO\'s larger initiative to set priorities for maternal, newborn, child, and adolescent health. We used the Child Health and Nutrition Research Initiative (CHNRI)

• Nakai et al showed that RTc and Tpeak

  2019-05-15

  

  Nakai et al. showed that RTc and Tpeak-end dispersion can be used to evaluate the spatial distribution of myocardial repolarization [15,16]. We measured RTc and Tpeak-end dispersion in the acute and chronic periods in the case reported herein. Both variables were increased during the acute period af

• The electrophysiological mechanisms underlying high

  2019-05-15

  

  The electrophysiological mechanisms underlying high frequency activity observed in the PLA during SRAF could be reentry (rotor) or focal discharges (triggered activity). To discriminate between these mechanisms, we perfused ryanodine (10–40μM) or caffeine (5mM) to abolish calcium overload-mediated t

• Generally patients with VVS do not need continuous

  2019-05-15

  

  Generally, patients with VVS do not need continuous cardiac pacing, but require physiological pacing only at the moment of the vasovagal response. Petersen et al. [7] reported the efficacy of permanent DDI pacing with rate hysteresis in selected patients who presented with cardioinhibitory VVS. Prev

• br D microCT data Bone

  2019-05-15

  

  3D microCT data Bone volume (BV/TV) ranged from 10.8 to 13.5% consistent with the published literature [18]. Trabecular thickness (Tb.Th), trabecular pi3k activation (Tb.Sp), trabecular number (Tb.N) and bone surface per tissue area (BS/TV) values were also consistent with the range published in

• Adhesive interactions Adhesive interactions between myeloma

  2019-05-15

  

  Adhesive interactions: Adhesive interactions between myeloma SC 144 and stromal cells play a significant role in both the homing of MM cells to the bone marrow and augmentation of the bone destructive process. These adhesive interactions result in activation of NF-κB and p38 MAP-kinase signaling, w

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